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The town of Tachileik and surrounding villages in Shan state appear to have borne the brunt of the earthquake.
There are fears the casualties could be much higher.
Burma is ill prepared to deal with natural disasters, says the BBC's Rachel Harvey in Bangkok.
Communication systems and infrastructure are poor and the military government, still in charge until the handover to a new civilian-led administration, tends to limit the flow of information.
It is likely to take some time before a clear picture of the disaster emerges, our correspondent says.
Several hundred buildings collapsed north of the town of Tachileik, in mountains near the border with Thailand.
Local people told the BBC that in the villages of Tarlay and Mong Lin alone more than 60 people had been killed. Roads and bridges have been damaged making affected areas hard to reach.
"We are trying to reach the remote areas," one official told AFP news agency. "The military, police and local authorities are trying to find some people injured in those affected areas but the roads are still closed."
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